Promising Solution Found In Gene Therapy Delivery

University of Colorado and University of Denver scientists are on the verge of finding out a solution to an old mechanical roadblock in the delivery of gene therapy. Dr. Corinne Lengsfeld, Associate professor, University of Denver said: Gene therapy has kind of come to a halt because we can’t get the DNA to the cell efficiently enough to make a difference The team of researchers analyzed as to why oral nebulizers-mist generating devices which forced compressed air through liquid medicine was a failure in delivering therapeutic genes. They have found out that cavitation was responsible for degradation of DNA within the nebulizers and hence the treatment was rendered ineffective when it reached the lungs. They have realized that if the turbulent eddy size was kept bigger than the DNA it would not fragment. This knowledge would be beneficial in developing methods for protecting genes on their way to the targeted cells.

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