Tag Archives: Down Syndrome

Can new embryo-screening technologies perk up IVF success rates?

Majority of women who are undergoing in vitro fertilization (IVF) are opting for preimplantation genetic screening as well. It is a kind of fetus testing that root out embryos with abnormal chromosomes. Since this kind of abnormality may bring about Down’s syndrome among babies. Existing screening techniques can only perceive a subset of abnormal embryos also, the doctors differ about whether the test substantially improves a patient’s chance of pregnancy or not. However, it has been expected that new testing technologies would act as catalyst in making IVF a great success. In 50% of the cases, human embryos are chromosomally abnormal, which means that instead of two, there may be three copies of chromosomes. Which however is 80% in women over 40. Chromosome testing accounts to about 2/3rd of preimplantation genetic screening. It other encircles tests for genetic diseases such as cystic fibrosis. Existing testing techniques employ particularly intended fluorescent probes that combine to the different chromosomes, exposing if there are either extra copies or not enough. Only 10 to 12 different probes can be used at a time, meaning that about half of the embryo’s 23 chromosome pairs go unscreened. So in order to take a thorough overview of the chromosomes, DNA micro arrays, a minute chip layered with DNA sequences could be employed. The biggest flaw in using this technique is that, it requires lots of genetic material, which is, however not available in a single cell that the scientists remove from an embryo. Dr. William G. Kearns is at the verge of developing a type of micro array which would perceive not only chromosomal abnormalities, but also some other genetic characteristics, like small duplications or deletions of DNA and genetic variations linked to single-gene disorders, which are presently spotted with a different process. It has been assumed that the new type of technique would reduce the rate of errors, as they cannot afford to give way to inaccuracy because of the limited available genetic material.

PTZ can help in controlling Down Syndrome

Stanford University researchers have found out that PTZ can help in improving the learning and memory of mice labs suffering from Down syndrome. Researchers discovered that a daily dose of PTZ drug enabled the Down syndrome mice to recognize objects and even navigate mazes just like a normal mice. Even after the discontinuation of the drugs the improvements lasted for up till two months. The researchers are satisfied with these findings and the researchers plan to conduct some more preliminary studies so that human trials could be carried out. Let me tell you that one of the major causes of mental retardation is the Down syndrome and it is caused due to an extra copy of chromosome 21. This is being regarded as a significant development which could help in controlling cases of mental retardation.