There is some good news for patients suffering from type 1 diabetes. Researchers at the UCLA have come up with a new vaccine that can help in the treatment of type 1 diabetes. The vaccine has been tested in humans and has been found useful. The drug named Diamyd is being checked for viability. Diamyd is based on researches on Glutamic Acid Decarboxylase. It is really unlikely that a drug for type 1 diabetes to be available for at least a few years. GAD was found successful in mice in Phase I. Phase II involved the testing of the drug on adults who have been recently diagnosed with diabetes. The results showed that the vaccine was effective in preserving the insulin production for at least 2 years. Type 1 diabetes generally begins in adolescence or may be even childhood. This kind of diabetes is characterized by the failure of the body to produce insulin, as the body’s immune system destroys the insulin producing cells of the pancreas.
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Are you a diabetes patient? then this news would certainly bring a ray of hope in your life. If Novocell is to be believed then the company might come up with an effective treatment against diabetes. Let me remind you that Novocell is a company which specializes in stem cell engineering. The company claims that it might be possible to repair insulin producing tissues which are affected by diabetes and said that stem cells from embryos could evolve and turn into cells which could provide insulin. If successful this treatment might be available in another three years. Emmanuel Baetge, chief scientific officer, Novocell said: The efficient, reproducible production of human embryonic stem cell derived, insulin producing endocrine cells through a process that mirrors the development of human pancreatic cells represents a critical step towards providing a renewable source of cells for diabetes therapy. This provides a foundation upon which we can build a standardized process for generating functional insulin-producing cells for the treatment of diabetic patients.
Some hope for diabetes patients. For the first time insulin secreting cells have been created from human embryonic stem cells which could lead to the unlimited supply of cells which might be transplanted into people suffering from type 1 diabetes. Researchers at Novocell used a combination of chemicals in order to wheedle the stem cells to produce pancreatic cells. These cells create as much insulin as normal pancreatic cells would produce but when compared with adult cells it was not regulated by sugar levels. If this test turns out to be successful, researchers have also found out a way of coating the cells in a polymer known as polyethylene glycol which would prevent the cells from rejection from recipients immune system and at the same time allow insulin, sugar and other molecules to filter in and out.
Researchers have found out that Resveratrol found in peanuts, natural foods, grape skins and red wines holds the secret for a happy and long life. A study conducted on mice confirmed this fact. A number of biotechnology companies are working to develop a treatment which would create the effect of resveratrol. Though researchers are still far off from making developments in this area but currently a company known as Sirtris Pharmaceuticals is working towards testing how safe resveratrol treatment is in case of diabetes patients. This compound has also been found out to prolong the life of organisms such as roundworms, yeast and fruit flies. Though a number of health food stores are selling resveratrol but it’s still unsure whether this compound would produce the same effect as it produced in mice and what could be the long term repercussions.
There is some good news for people suffering from obesity. Researchers at the University of California have discovered a small molecule which could play a pivotal role in controlling diabetes which is a slow killer disease and help in development of treatment for adult onset diabetes. Called as Boc5, this molecule leads to stimulation of insulin function in response to high glucose levels. It has also been found out to bring down the weight of a person by nearly twenty percent. This molecule leads to the production of intestinal hormone which metabolizes glucose. It is being labeled as the first small molecule activator for Class B GPCRs which leads to regulation of hormones in a number of human physiological processes. The discovery of Boc5 has opened up new avenues for supporting future research. It is expected that this molecule will help in controlling both diabetes and obesity which are some of the silent killer diseases.